கலை அண்ண இதை தமிழில் மொழி பெயர்க்கவும் ப்ளீஸ்

**இளமாறன்** · **இளமாறன்** Sat 9 Jul 2011 - 17:50

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எனக்கு மெயிலில் வந்த ஆங்கில செய்தி

LAB-MADE
ORGAN Implanted For First Time

By Madison Park, CNN
July 7,
2011 -- Updated 1815 GMT (0215 HKT)

கலை அண்ண இதை தமிழில் மொழி பெயர்க்கவும் ப்ளீஸ் - Page 2 T1larg.white.y.structure.harvard

கலை அண்ண இதை தமிழில் மொழி பெயர்க்கவும் ப்ளீஸ் - Page 2 T1larg.white.y.structure.harvard

Scientists created an
artificial trachea using polymers that had a s pongy and flexible
texture.

STORY
HIGHLIGHTS
In June,
doctors implanted an artificial trachea into a 36-year-old manThe organ was
created in a lab and bathed with the patient's stem cellsIt took away
the need for the patient to wait for a donor organ

RELATED
TOPICS
Organ Transplantation and DonationRegenerative MedicineBiotechnology

(CNN) -- For the first time, a
patient has received a synthetic windpipe that was created in a lab with the
patient's own stem cells and without using human donor tissue, researchers said
Thursday.

Previous lab-generated transplants
either used a segment of donor windpipe or involved tissue only, not an
organ.

In a laboratory in London,
scientists created a trachea, which is a tube-like airway that connects at the
voice box and branches into both lungs.

On June 9, doctors implanted this
synthetic windpipe into a 36-year-old man with late-stage tracheal cancer at
Karolinska University Hospital in Stockholm. The patient is doing well and is
expected to be released from the hospital Friday, said Dr. Paolo Macchiarini,
professor of regenerative medicine there.

Tracheal cancers are extremely rare,
accounting for less than 1% of all cancers.

After the patient's initial
diagnosis in 2008, he had exhausted every treatment available, including
chemotherapy, radiation and surgery, Macchiarini said. The patient, an Eritrean
who had been studying in Iceland, is the subject of a BBC documentary airing
Thursday in Sweden.

His tumor had almost blocked his
windpipe, doctors said.

Rather than waiting for a
transplant, his doctors suggested growing an organ. Scientists created a
Y-shaped framework for the new trachea, modeling it after the specific shape of
the patient's windpipe.

The form was made of polymers that
had a spongy and flexible texture. Stiff rings around the tube mimicked the
structure of a human trachea.

The form was then bathed in a
solution containing the patient's stem cells "to get the cells to grow on the
sponge material," said David Green, president of Harvard Bioscience. Stem cells
can divide and turn into a range of cell types, including those in
organs.
கலை அண்ண இதை தமிழில் மொழி பெயர்க்கவும் ப்ளீஸ் - Page 2 Story.pink.structure.harvard

கலை அண்ண இதை தமிழில் மொழி பெயர்க்கவும் ப்ளீஸ் - Page 2 Story.pink.structure.harvard

This is the
artificial trachea, covered in the patient's cells.
His company worked on the stem cell
solution, which is seen as a pink liquid in the photo at left. The purpose was
to "seed" the synthetic windpipe -- as you would seed a new lawn -- to grow on
the structure.

"Stem cells f rom the own patient
were growing inside and outside," Macchiarini said. "This structure was becoming
a living structure."

The stem cells were given physical
or chemical cues to create the desired type, Green said.

Once the cells were thriving on the
form, the artificial trachea was implanted into the patient.

His body accepted the new trachea,
and he even had a cough reflex two days after the surgery, Macchiarini
said.

Three years ago,
Macchiarini made headlines by implanting an artificial
trachea created from donor tissue combined with stem cells from the recipient,
Claudia Castillo, whose windpipe had been damaged by tuberculosis.

"The results were quite good, but
unfortunately we were still dependent" on organ donation, which can take months,
Macchiarini said.

Creating the synthetic structure for
the trachea in the current case took 10 to 12 days, compared with waiting months
for an organ donor, Macchiarini said.

Earlier this year, regenerative medicine scientists at Wake Forest University
School of Medicine reported that they had engineered five urethras between March
2004 and July 2007.

They had used a small piece of each
patient's own tissue from the bladder, then grew the cells in a lab onto a mesh
scaffold shaped like a urethra.

This area of research remains
somewhat controversial in medicine, because critics say this could lead to human
cloning.

But Macchiarini said making these
first artificial organs viable in patients opens doors for future transplants
through the relatively new field of regenerative medicine.

"It's a beautiful international
collaboration," he said about the recent effort that involved doctors and
researches in Sweden, the United Kingdom and the United States. "If scientists
and clinicians work together, we can help humanity."

ரேவதி · ரேவதி Sat 9 Jul 2011 - 18:33

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